Standard three-drug antiretroviral therapy (ART) �Cwhich typically contains two nucleoside/nucleotide reverse transcriptaseinhibitors (NRTIs) plus either a NNRTI, protease inhibitor or integraseinhibitor �C is safe and effective for most people with HIV. But a NRTI-sparingregimen may be an appropriate option for some people who experienceNRTI-related side effects or toxicities.
Franco Maggiolo from Azienda Ospedaliera Papa GiovanniXXIII in Bergamo, Italy, and colleagues conducted a prospective pilot study inwhich treatment-experienced people with undetectable viral load switched from astandard regimen to rilpivirine plus ritonavir-boosted darunavir.
This open-label trial included 60participants with stable viral suppression. Most (80%) were men and the averageage was 48 years.
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